Cancer is found at late stages more often in men than in women, according to a U.S. study that may provide insight into gender discrepancies in cancer outcomes since the more advanced the disease at diagnosis, the worse the prognosis tends to be.
Reviewing more than 2.4 million cases diagnosed from 2015 to 2022, researchers identified 16 cancers in which men were significantly more likely than women to be diagnosed after the disease had spread to local lymph nodes.
Such regional-stage diagnoses were 151% more likely in men than in women with tongue cancer, 93% more likely with salivary gland cancer, 80% more likely with oropharyngeal cancer, 74% more likely with thyroid cancer, and 67% more likely with stomach cancer, researchers noted in a report in Cancer Epidemiology, Biomarkers & Prevention.
Late-stage cancers that have spread to other organs were also more common than localized tumors in men versus women for 17 cancer sites, with the largest differences seen in melanoma and cancers of the tongue, thyroid, salivary gland, and stomach.
For a small number of cancer sites – including the larynx and the bladder – men were less likely than women to be diagnosed at later stages.
These patterns persisted across different races, ethnicities and neighborhood income levels.
One explanation could be differences in cancer screening rates, study leader Beth Maclin of the U.S. National Cancer Institute said in a statement.
And women see doctors more often than men, which could mean more opportunities for clinicians to catch cancer symptoms earlier, she noted. Clinicians may also perceive cancer symptoms differently in males and females, leading to different types of diagnostic tests, she added.